Inclusion & Exclusion Criteria
INCLUSION CRITERIA
General inclusion criteria:
AGE > 50 years
No history of supraventricular arrhythmia
Sinus rhythm at inclusion
CHADSVASc score > 2 in men (> 3 in female)
Written informed consent is obtained before any study-related assessment is performed
More than 3 specific criteria for inclusion
Specific criteria for inclusion:
Age > 65
Age > 75
BMI > 30
Heart failure with preserved LVEF (according to ESC GL for HF)
Ischemic stroke
Left atrial diameter > 45mm
Chronic obstructive pulmonary disease
Arterial hypertension
PR interval > 200ms
History of MI or (objective evidence of) chronic coronary syndrome
Peripheral artery disease
Thyroid disease
EXCLUSION CRITERIA
History of any supraventricular or ventricular arrhythmia (excluding premature contractions and 1st degree AV block)
Therapy with anticoagulants at the time of inclusion
Acute coronary syndrome less than one month prior to inclusion
History of cardiac surgery
Diabetes mellitus type 2
Reduced LVEF (<50%)
Acute or decompensated heart failure at the time of inclusion
Cardiomyopathy
Systemic inflammatory disease or acute inflammatory disease
Active malignancy
Alcoholism (≥ 8 drinks/week)
Renal Disease (Dialysis/ transplant/ CrCl < 1ml/s)
Liver disease (Cirrhosis/ transaminase > 3x ULT/ bilirubin > 2x ULT)
Severe or moderate mitral stenosis
Pregnancy